What is intelligence, and how is AI emergence a natural consequence of evolution? In his book "What Is Intelligence?" and in this conversation, Google's Blaise Agüera y Arcas takes up the idea that prediction is fundamental not only to intelligence and the brain but to life itself, and explores the wide-ranging implications. These include radical new perspectives on the computational properties of living systems, the evolutionary and social origins of intelligence, the relationship between models and reality, entropy and the nature of time, the meaning of free will, the problem of consciousness, and the ethics of machine intelligence.